Enhanced efficiency of recyclable C3-symmetric cinchonine-squaramides in the asymmetric Friedel–Crafts reaction of indoles with alkyl trifluoropyruvate.
DOI Number:
10.1016/j.tetasy.2012.08.015
Reaction Category:
RXNO ID:
RXNO_0000369
Educt:
indoles, alkyl trifluoropyruvate
Product:
substituted (S)-3,3,3-trifluoro-2-hydroxy-2-(1H-indol-3-yl)propanoate
Catalyst:
3,3′,3′′-[1,3,5-benzenetriyltris(methyleneimino)]tris[4-[(9R)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione
Cas No:
1346112-92-2
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5