Supported Bifunctional Chiral Thioureas as Catalysts in the Synthesis of 3‐Amino‐2‐Oxindoles through Enantioselective aza‐Friedel‐Crafts Reaction: Application in Continuous Flow Processes.

DOI Number:

10.1016/j.gresc.2022.07.004

Reaction Category:

RXNO ID:

RXNO_0000369

Educt:

tert-butyl (E)-(1-benzyl-2-oxo-7-(trifluoromethyl)indolin-3-ylidene)carbamate, naphthalen-1-ol

Product:

tert-butyl (R)-(1-benzyl-3-(1-hydroxynaphthalen-2-yl)-2-oxo-7-(trifluoromethyl)indolin-3-yl)carbamate

Catalyst:

supported N-[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]thiourea

Cas No:

2418549-11-6

Cas No:

522-66-7