Pilot-plant preparation of 3, 4-dihydropyridin-2-one derivatives, the core structures of P2X7 receptor antagonists.

DOI Number:

10.1021/op1000447
Link to literature

Reaction Category:

Desymmetrization

Educt:

4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione, methanol

Product:

(R)-3-(4-fluorophenyl)-5-methoxy-5-oxopentanoic acid

Catalyst:

N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-3,5-bis(trifluoromethyl)benzenesulfonamide

Cas No:

1092116-26-1

Associated Product from Buchler GmbH:

N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-3,5-bis(trifluoromethyl)benzenesulfonamide

Cas No:

1092116-26-1