Pilot-Plant Preparation of 3,4-Dihydropyridin-2-one Derivatives, the Core Structures of P2X7 Receptor Antagonists.
DOI Number:
10.1021/op1000447
Reaction Category:
Educt:
4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione, methanol
Product:
(R)-3-(4-fluorophenyl)-5-methoxy-5-oxopentanoic acid
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7