Highly enantioselective desymmetrization of meso anhydrides by a bifunctional thiourea-based organocatalyst at low catalyst loadings and room temperature.
DOI Number:
10.1021/jo702639h
Reaction Category:
Educt:
(3aR,4S,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione, methanol
Product:
(1R,2S,3R,4S)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0