Enantioselective cyclopropanation of (Z)-3-substituted-2-(4-pyridyl)-acrylonitriles catalyzed by Cinchona ammonium salts.

DOI Number:

10.1039/C6OB00154H
Link to literature

Reaction Category:

Cyclopropanation

Educt:

(Z)-3-substituted-2-(4-pyridyl)-acrylonitriles, diethyl 2-bromomalonate

Product:

substituted diethyl 2-cyano-2-(pyridin-4-yl)cyclopropane-1,1-dicarboxylate

Catalyst:

(9S)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-10,11-dihydro-9-hydroxy-6′-methoxy-cinchonanium bromide

Cas No:

1883793-76-7

Associated Product from Buchler GmbH:

Dihydroquinidine Base

Cas No:

1435-55-8