Intramolecular H‑Bonds in an Organocatalyst Enabled an Asymmetric Michael/Alkylation Cascade Reaction to Construct Spirooxindoles Incorporating a Densely Substituted Cyclopropane Motif.
DOI Number:
10.1021/acs.orglett.2c03578
Reaction Category:
Educt:
3-chloro-1-ethylindolin-2-one, 2-benzylidene-1H-indene-1,3(2H)-dione
Product:
(2'R,3'S)-1''-ethyl-3'-phenyldispiro[indene-2,1'-cyclopropane-2',3''-indoline]-1,2'',3-trione
Catalyst:
N-[(1R,2S)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl] thiourea
Cas No:
2128252-26-4
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0