Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation.
DOI Number:
10.1039/C2CC31445B
Reaction Category:
MOP ID:
MOP_0000561
Educt:
substituted (E)-2-acetylbut-2-enenitrile, cyclohexanone
Product:
2,4-disubstituted (4R,4aS,8aR)-8a-hydroxy-4a,5,6,7,8,8a-hexahydro-4H-chromene-3-carbonitrile
Catalyst:
(9R)-6′-methoxy-cinchonan-9-amine
Cas No:
287979-82-2
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2