Bifunctional squaramide catalysts with the same absolute chirality for the diastereodivergent access to densely functionalised cyclohexanes through enantioselective domino reactions. Synthesis and mechanistic studies.

DOI Number:

10.1002/adsc.201400502
Link to literature

Reaction Category:

Cascade reaction | Cyclization | Cyclization | Further Cyclizations | Henry | Henry | Michael | Michael Addition

RXNO ID:

RXNO_0000086

Educt:

substituted 2-nitro-5-oxopentanoate, (E)-1-nitroalk-1-enes

Product:

densely functionalised cyclohexanes

Catalyst:

3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl) ((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione

Cas No:

1073917-09-5

Associated Product from Buchler GmbH:

Quinidine Base

Cas No:

56-54-2