Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation.
DOI Number:
10.1039/C2CC31445B
Reaction Category:
MOP ID:
MOP_0000565
Educt:
substituted 2-formylacrylonitrile, cyclohexanone
Product:
substituted (4aS,8aR)-8a-hydroxy-4a,5,6,7,8,8a-hexahydro-4H-chromene-3-carbonitrile
Catalyst:
(9R)-10,11-Dihydro-6′-methoxycinchonan-9-amine
Cas No:
522600-31-3
Associated Product from Buchler GmbH:
Dihydroquinidine Base
Cas No:
1435-55-8