Diastereo-and Enantioselective Synthesis of Functionalized Cyclopentenes Containing a Quaternary Chiral Center via a Thiosquaramide-Catalyzed Cascade Michael–Henry Reaction.
DOI Number:
10.1021/acs.joc.9b02176
Reaction Category:
RXNO ID:
RXNO_0000086
Educt:
substituted 2-(2-oxoethyl)malononitrile, (E)-1-nitroalk-1-enes
Product:
2,4-disubstituted (1S,2R)-1-cyano-3-nitrocyclopent-3-ene-1-carboxamide
Catalyst:
3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dithione
Cas No:
2390162-31-7
Associated Product from Buchler GmbH:
Quinidine Base
Cas No:
56-54-2