Direct Catalytic Enantioselective Reaction of α-Isocyanoacetonitriles with Ketimines Using Cinchona Alkaloid Amide–Cu (II) Catalysts.

DOI Number:

10.1021/acs.orglett.3c00259
Link to literature

Reaction Category:

Cyclization | Cyclization | Further Cyclizations

MOP ID:

MOP_0000561

Educt:

ketimines, α-isocyanoacetonitriles

Product:

4,5,5-trisubstituted (4R)-1-(diphenylphosphoryl)-4,5-dihydro-1H-imidazole-4-carbonitrile

Catalyst:

N-(9R)-Cinchonan-9-yl-2-pyridinecarboxamide

Cas No:

1414851-55-0

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5