Catalytic asymmetric synthesis of vicinal tetrasubstituted diamines via umpolung cross-Mannich reaction of cyclic ketimines.
DOI Number:
10.1021/acs.orglett.0c01578
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
N/C-substituted (E)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate
Product:
N/C-substituted tert-butyl ((3S,3'R)-2,2'-dioxo-3-(((E)-2,2,2-trifluoroethylidene)amino)-[3,3'-biindolin]-3'-yl)carbamate
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0