Catalytic asymmetric synthesis of vicinal tetrasubstituted diamines via umpolung cross-Mannich reaction of cyclic ketimines.

DOI Number:

10.1021/acs.orglett.0c01578
Link to literature

Reaction Category:

Mannich

RXNO ID:

RXNO_0000032

Educt:

N/C-substituted (E)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate

Product:

N/C-substituted tert-butyl ((3S,3'R)-2,2'-dioxo-3-(((E)-2,2,2-trifluoroethylidene)amino)-[3,3'-biindolin]-3'-yl)carbamate

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0