Catalytic Asymmetric Chlorocyclization of 2-Vinylphenylcarbamates for Synthesis of 1,4-Dihydro-2H-3,1-benzoxazin-2-one Derivatives.

DOI Number:

10.1021/acs.orglett.7b00272
Link to literature

Reaction Category:

Chlorination | Cyclization | Further Cyclizations | Intramolecular cyclization | Lactonization

MOP ID:

MOP_0000551

Educt:

substituted tert-butyl (2-(1-substituted-vinyl)phenyl)carbamate, 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione

Product:

subsituted (S)-4-(chloromethyl)-4-substituted-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one

Catalyst:

(8α,9R)-9-[2-[bis(2-methylphenyl) amino]benzoate]-cinchonan-9-ol

Cas No:

2084883-75-8

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5