Synthesis of six-membered spirocyclic oxindoles with five consecutive stereocenters in an asymmetric organocatalytic one-pot Michael/Michael/aldol addition sequence.
DOI Number:
10.1021/jo302655u
Reaction Category:
Educt:
substituted indolin-2-one, nitroalkenes, α,β-unsaturated aldehydes
Product:
spirocyclic oxindoles
Catalyst:
(S)-2-(diphenyl((trimethylsilyl)oxy)methyl)pyrrolidine, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0