A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines.

DOI Number:

10.1039/C2OB25327E
Link to literature

Reaction Category:

Bromination | Cyclization | Cyclization | Cycloaddition | Further Cyclizations | Intramolecular cyclization

MOP ID:

MOP_0000551

Educt:

(E)-substituted N-(but-3-en-1-yl)-4-nitrobenzenesulfonamide, 2-bromoisoindoline-1,3-dione

Product:

2-substituted (2S,3R)-3-bromo-1-((4-nitrophenyl)sulfonyl)pyrrolidine

Catalyst:

(9S)-9-[N-(2,6-diethoxyphenyl)carbamothioate]-cinchonan-9-ol

Cas No:

1374877-37-8

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5