Asymmetric synthesis of highly functionalized γ-lactams through an organocatalytic aza-Michael–Michael reaction cascade using fumaric acid amide esters as multi-reactive substrates.
DOI Number:
10.1016/j.tetlet.2011.12.114
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
cyclohex-2-en-1-one, ethyl (E)-4-((benzyloxy)amino)-4-oxobut-2-enoate
Product:
ethyl 2-((3S,3aS,7aS)-1-(benzyloxy)-2,4-dioxooctahydro-1H-indol-3-yl)acetate
Catalyst:
(8α,9S)-6′-Methoxycinchonan-9-amine
Cas No:
168960-95-0
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0