Enantioselective Synthesis of (R)-Sitagliptin via Phase-Transfer Catalytic aza-Michael Addition.
DOI Number:
10.1021/acsomega.3c10080
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
tert-butyl (naphthalen-2-ylmethoxy)carbamate, (E)-1-(4-Methoxyphenyl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one
Product:
(R)-tert-Butyl-(4-(4-Methoxyphenyl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)(naphthalen-2-ylmethoxy)carbamate
Catalyst:
(8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]- 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6′-methoxy-Cinchonanium bromide
Cas No:
2762290-06-0
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0