Enantioselective Synthesis of (R)-Sitagliptin via Phase-Transfer Catalytic aza-Michael Addition.

DOI Number:

10.1021/acsomega.3c10080
Link to literature

Reaction Category:

Aza-Michael | Michael Addition

RXNO ID:

RXNO_0000009

Educt:

tert-butyl (naphthalen-2-ylmethoxy)carbamate, (E)-1-(4-Methoxyphenyl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one

Product:

(R)-tert-Butyl-(4-(4-Methoxyphenyl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)(naphthalen-2-ylmethoxy)carbamate

Catalyst:

(8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]- 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6′-methoxy-Cinchonanium bromide

Cas No:

2762290-06-0

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0