Squaramide-catalysed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral trisubstituted pyrrolidines.
DOI Number:
10.1039/C5OB01749A
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
nitroalkenes, tosyl protected δ‐amino-α,β-unsaturated ketones
Product:
trisubstituted pyrrolidines
Catalyst:
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1352957-59-5
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7