Tandem Rh (II) and Chiral Squaramide Relay Catalysis: Enantioselective Synthesis of Dihydro-β-carbolines via Insertion to C–H Bond and Aza-Michael Reaction.
DOI Number:
10.1021/acs.orglett.9b00652
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
(E)-3-(1-methylindolin-2-yl)-1-phenylprop-2-en-1-one, 4-phenyl-1-(phenylsulfonyl)-1H-1,2,3-triazole
Product:
2-((1R)-9-methyl-4-phenyl-2-(phenylsulfonyl)-2,4a,9,9a-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-1-phenylethan-1-one
Catalyst:
rhodium(II) acetate, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[(phenylmethyl)amino]-3-Cyclobutene-1,2-dione
Cas No:
1228363-03-8
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2