Supported Bifunctional Chiral Thioureas as Catalysts in the Synthesis of 3-Amino-2-Oxindoles through Enantioselective aza-Friedel-Crafts Reaction: Application in Continuous Flow Processes.
DOI Number:
10.1002/adsc.202000238
Reaction Category:
RXNO ID:
RXNO_0000369
Educt:
tert-butyl (E)-(1-benzyl-2-oxoindolin-3-ylidene)carbamates, naphthols
Product:
tert-butyl (R)-(1-benzyl-3-(1-hydroxynaphthalen-2-yl)-2-oxoindolin-3-yl)carbamates
Catalyst:
N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-Thiourea (aminoalkyl polystyrene resin-supported)
Cas No:
2418549-11-6
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7