Highly enantioselective amination of α-substituted α-cyanoacetates with chiral catalysts accessible from both quinine and quinidine.

DOI Number:

10.1021/ol048190w
Link to literature

Reaction Category:

alpha-Amination | Amination

Educt:

α-substituted α-cyanoacetates, disubstituted (E)-diazene-1,2-dicarboxylate

Product:

substituted 1-(1-cyano-2-ethoxy-2-oxoethyl)hydrazine-1,2-dicarboxylate

Catalyst:

(9S)-9-(phenylmethoxy)-cinchonan-6′-ol

Cas No:

761434-35-9

Associated Product from Buchler GmbH:

Cupreidine Base

Cas No:

70877-75-7