Scalable methodology for the catalytic, asymmetric α-bromination of acid chlorides.

DOI Number:

10.1021/jo061522l
Link to literature

Reaction Category:

Bromination

MOP ID:

MOP_0000551

Educt:

acid chlorides, 2,2,4,7-tetrabromonaphthalen-1(2H)-one

Product:

2,4,7-tribromonaphthalen-1-yl 2-substituted-2-bromoacetates

Catalyst:

6′-methoxy-(8α,9R)-Cinchonan-9-ol 9-[1-(1,1-dimethylethyl) (2R)-1,2-pyrrolidinedicarboxylate]

Cas No:

916748-40-8

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0