Asymmetric Synthesis of α-Fluoro-β-Amino-oxindoles with Tetrasubstituted C–F Stereogenic Centers via Cooperative Cation-Binding Catalysis.

DOI Number:

10.1021/acs.orglett.7b02628
Link to literature

Reaction Category:

Aldol | Aldol

RXNO ID:

RXNO_0000016

Educt:

substituted 3-fluoro-indolin-2-ones, paraformaldehyde

Product:

substituted (S)-3-fluoro-3-(hydroxymethyl)indolin-2-ones

Catalyst:

(8α,9R)-Cinchonan-6′,9-diol-9-benzoate

Cas No:

876269-54-4

Associated Product from Buchler GmbH:

Cupreine Base

Cas No:

524-63-0