Stereoselective Organocatalyzed Synthesis of α-Fluorinated β-Amino Thioesters and Their Application in Peptide Synthesis.

DOI Number:

10.1002/anie.201607146

Reaction Category:

Educt:

methyl 2-fluoro-3-((2-fluorophenyl)thio)-3-oxopropanoate, tert-butyl (E)-benzylidenecarbamate

Product:

methyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-fluoro-2-(((2-fluorophenyl)thio)carbonyl)-3-phenylpropanoate

Catalyst:

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1352957-59-5

Cas No:

522-66-7