Organocatalytic Enantioselective Synthesis of Chiral Spiro-indoline-pyrazolones through a formal [4 + 1] Annulation Reaction of 4-Bromopyrazolones and aza-ortho-Quinone Methides.
DOI Number:
10.1002/hlca.202400029
Reaction Category:
MOP ID:
MOP_0000561
Educt:
N-(2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide, 4-bromo-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Product:
(R)-3'-methyl-1'-phenyl-1-tosylspiro[indoline-2,4'-pyrazol]-5'(1'H)-one
Catalyst:
3,4-bis[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione
Cas No:
1204591-48-9
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0