Organocatalytic Enantioselective Synthesis of Chiral Spiro-indoline-pyrazolones through a formal [4 + 1] Annulation Reaction of 4-Bromopyrazolones and aza-ortho-Quinone Methides.

DOI Number:

10.1002/hlca.202400029

Reaction Category:

MOP ID:

MOP_0000561

Educt:

N-(2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide, 4-bromo-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

Product:

(R)-3'-methyl-1'-phenyl-1-tosylspiro[indoline-2,4'-pyrazol]-5'(1'H)-one

Catalyst:

3,4-bis[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

1204591-48-9

Cas No:

130-95-0