Asymmetric Synthesis of Bispiro[γ-butyrolactone-pyrrolidin-4,4′-pyrazolone] Scaffolds Containing Two Quaternary Spirocenters via an Organocatalytic 1,3-Dipolar Cycloaddition.
DOI Number:
10.1002/ejoc.201800404
Reaction Category:
RXNO ID:
RXNO_0000018
Educt:
(Z)-2,4-Dihydro-5-methyl-2-phenyl-4-(phenylmethylene)-3H-pyrazol-3-one, (E)-Dihydro-3-[(2-thienylmethylene)amino]-2(3H)-furanone
Product:
(5S,6R,7R,13R)-4-Methyl-2,6-diphenyl-13-(2-thienyl)-9-oxa-2,3,12-triazadispiro[4.1.4.2]tridec-3-ene-1,8-dione
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0