Thorpe-Ziegler reaction is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.

Thorpe-Ziegler reaction examples catalyzed by cinchona alkaloid derivatives can be found in our free of charge Chiral Catalyst Search.

Example from Literature

Organocatalyzed enantioselective synthesis of 6-amino-5-cyanodihydropyrano[2,3-c]pyrazoles. (Gogoi et al.; Tetrahedron Lett. 2009, 50, 19, 2252-2255.)