A cinchona alkaloid catalyzed enantioselective sulfa-Michael/aldol cascade reaction of isoindigos: construction of chiral bispirooxindole tetrahydrothiophenes with vicinal quaternary spirocenters.

DOI Number:

10.1039/c5ob00774g

Reaction Category:

RXNO ID:

RXNO_0000016

Educt:

1,4-dithiane-2,5-diol, N/C-substituted-(E)-[3,3'-biindolinylidene]-2,2'-dione

Product:

N/C-substituted-(3S,3'R,4'R)-4'-hydroxy-4',5'-dihydrodispiro[indoline-3,2'-thiophene-3',3''-indoline]-2,2''-dione

Catalyst:

Quinine Base

Cas No:

130-95-0

Cas No:

130-95-0