Cascade Aza-Michael/Michael Addition, (E)-N-(2-(3-substituted-3-oxoprop-1-en-1-yl)phenyl)-4-methylbenzenesulfonamide, substituted (E)-3-(2-subsituted-2-oxoethylidene)indolin-2-one, spirooxindole tetrahydroquinolines, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine Derivative

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines.

DOI Number:

10.1039/C3CC44930K

Link to literature

Reaction Category:

Cascade reaction | Spirocyclization

Educt:

(E)-N-(2-(3-substituted-3-oxoprop-1-en-1-yl)phenyl)-4-methylbenzenesulfonamide, substituted (E)-3-(2-subsituted-2-oxoethylidene)indolin-2-one

Product:

spirooxindole tetrahydroquinolines

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

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Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0