Catalytic, Asymmetric α-Fluorination of Acid Chlorides: Dual Metal−Ketene Enolate Activation.

DOI Number:

10.1021/ja807792c

Reaction Category:

MOP ID:

MOP_0000553

Educt:

2-(4-methoxyphenyl)acetyl chloride, tert-butyl (S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide

Product:

tert-butyl (S)-2-(((R)-2-fluoro-2-(4-methoxyphenyl)acetoxy)methyl)pyrrolidine-1-carboxylate

Catalyst:

Dichloro[1,3-bis(diphenylphosphino)propane]nickel, 6′-methoxy-(9S)-Cinchonan-9-ol-9-benzoate

Cas No:

60723-45-7

Cas No:

56-54-2