Organocatalytic Enantioselective Synthesis of α‑Hydroxyketones through a Friedel−Crafts Reaction of Naphthols and Activated Phenols with Aryl- and Alkylglyoxal Hydrates.
DOI Number:
10.1021/acs.orglett.6b02893
Reaction Category:
RXNO ID:
RXNO_0000369
Educt:
1-naphtol, 2,2-dihydroxy-1-phenylethan-1-one
Product:
(R)-2-hydroxy-2-(1-hydroxynaphthalen-2-yl)-1-phenylethan-1-one
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0