LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor

DOI Number:

10.1002/anie.201501394

Reaction Category:

RXNO ID:

RXNO_0000235

Educt:

tert-butyl (Z)-(4-chlorobenzylidene)carbamate, methyl 3-methyl-4-nitrobutanoate

Product:

methyl (4S,5R)-5-((tert-butoxycarbonyl)amino)-5-(4-chlorophenyl)-3-methyl-4-nitropentanoate

Catalyst:

(1S,2R,4S,5R)-1-benzyl-2-((R)-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide

Cas No:

1374880-10-0

Cas No:

56-54-2