Highly chemo- and enantioselective vinylogous aldol/cyclization cascade reaction to construct chiral 5,6-dihydropyran-2-ones.

DOI Number:

10.1016/j.tet.2018.05.011
Link to literature

Reaction Category:

Cascade reaction | Cyclization | Lactonization

MOP ID:

MOP_0000561

Educt:

beta,gamma-unsaturated amides, beta,gamma-unsaturated alpha-ketoesters

Product:

5,6-dihydropyran-2-ones

Catalyst:

1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea

Cas No:

851477-19-5

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5