Synthesis of 2-oxindoles sharing vicinal all-carbon quaternary stereocenters via organocatalytic aldol reaction.

DOI Number:

10.1021/acs.joc.6b02195
Link to literature

Reaction Category:

Aldol | Aldol | Spirocyclization

RXNO ID:

RXNO_0000016

Educt:

N-protected [3,3'-biindoline]-2,2'-dione, formaldehyde

Product:

N-protected (3R)-4-(2-aminophenyl)-2H-spiro[furan-3,3'-indoline]-2',5(4H)-dione

Catalyst:

N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea

Cas No:

851477-19-5

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5