Asymmetric vinylogous Michael addition of 5-substituted-furan-2(3H)-ones to an α,β-unsaturated-γ-lactam.
DOI Number:
10.1039/D0OB01750G
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
5-methylfuran-2(3H)-one, tert-butyl 2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate
Product:
tert-butyl (R)-4-((R)-2-methyl-5-oxo-2,5-dihydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea
Cas No:
890044-38-9
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2