Asymmetric catalytic access to piperazin-2-ones and morpholin-2-ones in a one-pot approach: rapid synthesis of an intermediate to aprepitant.
DOI Number:
10.1021/acs.joc.2c02491
Reaction Category:
MOP ID:
MOP_0000561
Educt:
(phenylsulfonyl)acetonitrile, 4-fluorobenzaldehyde, 2-(benzylamino)ethan-1-ol
Product:
(R)-4-benzyl-3-(4-fluorophenyl)morpholin-2-one
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea
Cas No:
957770-66-0
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea
Cas No:
957770-66-0