A highly enantioselective Biginelli reaction using self-assembled methanoproline–thiourea organocatalysts: asymmetric synthesis of 6-isopropyl-3,4-dihydropyrimidines.
DOI Number:
10.1039/C5CC07880F
Reaction Category:
RXNO ID:
RXNO_0000236
Educt:
aldehydes, thiourea, 4-methyl-3-oxopentanoic acid esters
Product:
6-isopropyl-3,4-dihydropyrimidines
Catalyst:
(1R,3S,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7