Highly enantioselective Biginelli reactions using methanopyroline/thiourea – based dual organocatalyst systems: asymmetric synthesis of 4-substituted unsaturated aryl dihydropyrimidines.
DOI Number:
10.1016/j.tetasy.2016.11.015
Reaction Category:
RXNO ID:
RXNO_0000236
Educt:
α,β-unsaturated aldehydes, thiourea, β-ketoesters
Product:
3,4-dihydro-pyrimidin-2-(1H)-thiones
Catalyst:
trans-4,5-methano-L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7