Cinchona alkaloid squaramide-catalyzed asymmetric michael addition of α-aryl isocyanoacetates to β-trifluoromethylated enones and its applications in the synthesis of chiral β-trifluoromethylated pyrrolines.
DOI Number:
10.1021/acs.joc.5b01829
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
α-aryl isocyanoacetates, β-trifluoromethylated enones
Product:
substituted (3S)-2-isocyano-5-oxo-3-(trifluoromethyl)pentanoate
Catalyst:
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1352957-59-5
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7