Asymmetric synthesis of poly-substituted spirocyclohexane oxindole via a squaramide catalyzed cascade Michael–Michael–aldol sequence.

DOI Number:

10.1039/C4QO00299G
Link to literature

Reaction Category:

Cascade reaction | Spirocyclization

Educt:

ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, pentane-2,4-dione, (E)-(2-nitrovinyl)benzene

Product:

poly-substituted spirocyclohexane oxindole

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1210360-60-3

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0