An efficient synthesis of (S)-3-aminomethyl-5-methylhexanoic acid (Pregabalin) via quinine-mediated desymmetrization of cyclic anhydride.
DOI Number:
10.1016/j.tetasy.2007.06.014
Reaction Category:
Educt:
3-isobutylglutaric anhydride, cinnamyl alcohol
Product:
(R)-3-(2-(cinnamyloxy)-2-oxoethyl)-5-methylhexanoic acid
Catalyst:
Quinine Base
Cas No:
130-95-0
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0