Stereodivergent synthesis of enantioenriched 2,3-disubstituted dihydrobenzofurans via a one-pot C–H functionalization/oxa-michael addition cascade.
DOI Number:
10.1021/jacs.1c03498
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
3-(pyrrolidin-1-yl)phenol, 2,6-dichlorophenyl (E)-2-diazo-4-phenylbut-3-enoate
Product:
2,3-disubstituted dihydrobenzofurans
Catalyst:
rhodium catalyst, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0