Highly enantioselective organocatalyzed vinylogous Michael-type reaction for the construction of trifluoromethylated all-carbon quaternary stereocenters.
DOI Number:
10.1021/ol500157b
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate, (E)-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene
Product:
tert-butyl (R,Z)-2-oxo-3-(5,5,5-trifluoro-4-(nitromethyl)-4-phenylpentan-2-ylidene)indoline-1-carboxylate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0