Asymmetric Sequential Vinylogous Mannich/Annulation/Acylation Process of 2‐Ethylidene 1, 3‐Indandiones and Isatin N‐Boc Ketimines: Access to Chiral Spiro‐Oxindole Piperidine Derivatives.
DOI Number:
10.1002/adsc.202200465
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
2‐ethylidene-1,3‐indandiones, isatin N‐Boc ketimines
Product:
tert-butyl (S)-(1-benzyl-3-(2-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)-2-phenylethyl)-5-methoxy-2-oxoindolin-3-yl)carbamate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7
Associated Product from Buchler GmbH:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea
Cas No:
852913-16-7