Michael addition of oxindoles to N-(2-tert-Butylphenyl) maleimides: efficient desymmetrization for the synthesis of atropisomeric succinimides with quaternary and tertiary stereocenters.
DOI Number:
10.1055/s-0036-1588408
Reaction Category:
Educt:
tert-butyl 7-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 1-(2-(tert-butyl)phenyl)-1H-pyrrole-2,5-dione
Product:
tert-butyl (R)-3-((S)-1-(2-(tert-butyl)phenyl)-2,5-dioxopyrrolidin-3-yl)-7-fluoro-2-oxo-3-phenylindoline-1-carboxylate
Catalyst:
3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione
Cas No:
1223105-69-8
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2