Asymmetric Catalytic Access to Piperazin-2-ones and Morpholin-2-ones in a One-Pot Approach: Rapid Synthesis of an Intermediate to Aprepitant.

DOI Number:

10.1021/acs.joc.2c02491
Link to literature

Reaction Category:

Cascade reaction

Educt:

4-cyanobenzaldehyde, 2-(phenylsulfonyl)acetonitrile, benzathine

Product:

(R)-4-(1,4-dibenzyl-3-oxopiperazin-2-yl)benzonitrile

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-6′-methoxycinchonan-9-yl]urea

Cas No:

957770-66-0

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea

Cas No:

957770-66-0