One-pot enantioselective synthesis of 2-pyrrolidinone derivatives bearing a trifluoromethylated all-carbon quaternary stereocenter.

DOI Number:

10.1021/acs.orglett.9b03758
Link to literature

Reaction Category:

Michael | Michael Addition

RXNO ID:

RXNO_0000009

Educt:

tert-butyl (Z)-3-(3-ethoxy-1,1,1-trifluoro-3-oxopropan-2-ylidene)-2-oxoindoline-1-carboxylate, nitromethane

Product:

tert-butyl (S)-3-((S)-3-ethoxy-1,1,1-trifluoro-2-(nitromethyl)-3-oxopropan-2-yl)-2-oxoindoline-1-carboxylate

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-86-9

Associated Product from Buchler GmbH:

Cinchonidine Base

Cas No:

485-71-2