Chiral squaramide catalyzed synthesis of C4 substituted chiral pyrazol-3-ol derivatives via a facile asymmetric Michael addition of 3-methyl-2-pyrazolin-5-one to b-nitrostyrenes.
DOI Number:
10.1016/j.tetlet.2016.02.008
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, (E)-(2-nitrovinyl)benzene
Product:
(R)-3-methyl-4-(2-nitro-1-phenylethyl)-1-phenyl-1H-pyrazol-5-ol
Catalyst:
3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1210360-60-3
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0