Enantioselective organocatalysis is the best method to obtain an enantiopure compound at a high yield compared with other methods. Chiral organocatalysts without metal atoms have gained interest to ensure the same efficacy, inexpensive, and much greener environmental sustainability in recent years, especially for the pharmaceutical industry to remove metal-containing compounds from the production process to achieve the lowest concentration of trace metals in the final product. Since these catalysts are resistant to air moisture and easy to handle, they do not require any additional requirements in the production line compared with metal-containing catalysts and enzymes.